Endocrine Abstracts

We report a 29-year old primiparous woman, presenting 3-days post vaginal delivery with a severe frontal headache of gradual onset but particularly severe whenever she tried breastfeeding and accompanied by vomiting. She was conscious, mildly dehydrated and apyrexial. Reflexes were globally brisk and besides for neck stiffness the rest of her central nervous system and major systemic examination was normal. FBC and clotting were normal, C-reactive protein 35 (normal <5). G...

We report a 26 year old Asian lady referred to our clinic with secondary infertility and a raised testosterone. She had miscarried at 6 weeks a year earlier. Over the last 6 months her periods had become irregular (every 6–8 weeks) had gained 9 kilograms in weight despite an unchanged diet. Along with this she had noticed an increase in facial and body hair. Testosterone checked by her GP was markedly elevated at 5.2 nmols/L (N<2.8).Prolactin 214 mu/L (0–650), ...

Introduction: The incidence of adrenal insufficiency in cases of unexplained death in young children is unclear. It is also unclear whether there is a relationship between adrenal size and plasma cortisol concentration.Methods: All post-mortem (PM) reports of sudden deaths in children in the West of Scotland between 2010 and 2012 were retrospectively analysed. Combined adrenal weight (g) was recorded and expressed as the percentage of total body weight (...

Introduction: Stimulated serum C-peptide (sCP) during a mixed meal tolerance test (MMTT) is the gold standard measure of endogenous insulin secretion in Type 1 diabetes (T1D). However invasiveness of sampling, the need to discontinue insulin prior to testing and rapid processing of samples limits its widespread use, particularly in children. Practical alternatives would increase utility.Aims: To assess if in a MMTT: 1.It is necessary to omit insulin. 2. ...

Introduction: There is increasing evidence suggesting that adiponectin plays a role in the regulation of bone metabolism. We have studied the changes in the circulating concentration of adiponectin in lean and obese post-menopausal women with and without osteoporosis and its association with a marker of bone formation – type 1 procollagen amino-terminal pro-peptide (P1NP) and a marker of bone resorption – type 1 collagen C-telopeptide (βCTX).<p class="abstex...

Context: Angiopoietin-like protein 4 (Angptl4) is a protein involved in lipolysis, that is regulated by non-esterified free fatty acids (FFA). GH promotes lipolysis and increases circulating FFA. Hypothesis: GH increases circulating Angptl4 levels by modulating its expression and secretion from fat and muscle. Angptl4 might be of metabolic relevance for the insulin resistance associated with GH/IGF1 excess or deficiency.Objective: To evaluate Angptl4 in ...

Background: It is generally believed that glycemic targets in diabetic pregnancies should mimic those found in normal pregnancies.Aim: The aim of the present work was to reveal how glycemia indices in pregnant patients with type 1 diabetes mellitus (T1DM), their infants’ birth weight (IBW).Methods: Totally, 128 pregnant women with T1DM were enrolled in the study (mean age – 26±7 yrs; diabetes duration – 10.2&#17...

Intra-adipose steroid metabolism may be a key determinant of accumulation and distribution of body fat. Adverse 'central' fat can be driven by glucocorticoid excess or decreased oestrogen/androgen ratio. We previously demonstrated increased regeneration of cortisol by 11beta-HSD1 in adipose in human obesity. Here, we measured mRNAs for enzymes dictating local activation of oestrogens (aromatase) and androgens (5alpha-reductase type 1) in subcutaneous human adipose and related ...

Recent studies have suggested that upper body adiposity is associated with major cardiovascular risk (CVR). However most of them were conducted in obese patients. This study aimed to evaluate the relationship of neck circumference (NC) in a non-obese Brazilian adult population, considering that it would be a simple and time-saving measurement to identify patients with worse cardiometabolic profile. We evaluated 279 non-obese Brazilian adults [86 men (♂), 193 women (&#979...

Background: There are no data concerning a relationship between alcohol and bone status of elderly Spanish men. Previous studies in other countries on the influence of alcohol intake on bone mineral density (BMD) in men are inconsistent and the effect of these variables on BMD is yet to be explored.Objective: The aim of this study was to describe the associations between total and beverage-specific alcohol intake and both BMD and bone ultrasound in elder...